The article discusses the nature and significance of the settlement of the area bordered by Ašmenos, Mėsinių and Dysnos Streets in early Vilnius, and the links with the German Town. The period of research was chosen - from the first traces of human activity in this part of Vilnius to the 16th century, with particular emphasis on the earliest period - late 14th century - the first half of the 15th century, which is the least covered in Vilnius studies.