The article deals with the patronage of art by the Radvila women of the Nesvizh-Olyka branch of the family. It is seen as a complex organisational process that involved not only clients but also intermediaries. The aim is to reveal the typical roles of female patrons, identify the areas of art they supported the most, and assess the individual contribution of women. Research into the women’s activities during the Wettin period helps to reveal an important and still underestimated aspect of the social history of art in the Grand Duchy of Lithuania: the importance of family ties and cooperation in art commissions. The women often acted as intermediaries for their spouses and mother, Ona Sanguškaitė-Radvilienė. Compared to Western European countries, in the eighteenth century, the Grand Duchy of Lithuania had a poorly developed network of art agents and specialised art dealers. Therefore family ties and women’s mediation were crucial both in the hiring of artists and in the control of their work.